Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In this study, we stably transfected human breast tumor MCF-7 cells with short hairpin RNA expression vectors targeting HIF-1alpha.
|
16516853 |
2006 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The NCI Open Repository of marine invertebrates and algae lipid extracts was evaluated for HIF-1 inhibitory activity in a T47D human breast tumor cell-based reporter assay.
|
17958397 |
2007 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer.
|
15656883 |
2005 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Extracellular matrix and HIF-1 signaling: the role of prolidase.
|
17999410 |
2008 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Last, clinically relevant correlations between miR-18a, HIF1A, hypoxia-responsive gene expression and distant metastasis-free survival (DMFS) were assessed using published expression array breast tumors data sets.
|
25069832 |
2014 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells.
|
17676480 |
2007 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
UCP is detected coincidently with HIF-1alpha in human primary liver, colon and breast tumors, and metastatic cholangiocarcinoma and colon cancer cells.
|
16819549 |
2006 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We hypothesize that inhibitors of HIF-1α or the proteasome might stabilize ER-α expression in breast tumors in vivo, and work in combination with endocrine therapies to reduce resistance.
|
28320353 |
2017 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer.
|
16555123 |
2006 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?
|
15084243 |
2004 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study is the first to identify HIF-1α as a modulator of PII-driven aromatase expression in human breast tumor-associated stroma and provides a novel mechanism for estrogen regulation in obesity-related, post-menopausal breast cancer.
|
23566437 |
2013 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha.
|
17653093 |
2008 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Intratumoral hypoxia may explain elevated CA in vivo because exposure of cultured cells to hypoxia or mimicking hypoxia pharmacologically or genetically increases CA, and HIF-1α and hypoxic gene signature expression correlate with CA and centrosomal gene signature expression in breast tumors.
|
28272508 |
2017 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
At 73/74 wk, both modes of calorie restriction lowered IGF-I protein expression levels and Akt activation in MTs and mammary fat pads, and CCR increased mTOR, p70S6K, p4EBP1, and HIF-1 expression.
|
21462085 |
2011 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study demonstrates that HIF-1α is involved in the transcriptional regulation of the TFPI gene, and suggests that a hypoxic microenvironment inside a breast tumor may induce a procoagulant state in breast cancer patients.
|
26598923 |
2016 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We hypothesised that either somatic mutation or hypermethylation of the CITED4 gene underlies CITED4 down-regulation and thus enhanced HIF-1α expression in some breast tumours.
|
21755341 |
2011 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer.
|
16899602 |
2006 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here, we showed that the epigenetic reader zinc finger MYND-type containing 8 (ZMYND8) is induced by HIF-1 and HIF-2 in breast cancer cells and also upregulated in human breast tumors, and is correlated with poor survival of patients with breast cancer.
|
29629903 |
2018 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.
|
17805961 |
2008 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α).
|
29959560 |
2018 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
|
29180628 |
2017 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition, we have found that factor 26 (1q CNA) is negatively correlated with HIF-1alpha protein and hypoxia pathways in breast tumors and cell lines.
|
20824128 |
2010 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α-induced pro-angiogenic factor.
|
29532562 |
2018 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription.
|
26287601 |
2015 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1α-mediated VEGF-dependent angiogenesis.
|
23728336 |
2014 |